Familial Mediterranean Fever | MEFV full gene sequencing

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Familial Mediterranean fever (FMF) is an inherited condition which causes episodic attacks of fever and painful inflammation of the abdomen, chest, and joints. FMF patiens may also develop a rash during these attacks. The episodes last for 1 to 3 days and can vary in severity. Between episodes the patient typically feels normal. These symptom-free periods can last for days or even years.

In 80-90% of people affected by FMF, the first episode occurs by the age of 20. Less commonly, symptoms begin later in life. Children who have FMF may experience periodic fever as their only symptom.

FMF is caused by mutations in MEFV gene and is inherited in an autosomal recessive pattern.

Method

Analysis of the MEFV gene (all coding exons and adjascent intron-exon boundaries) using bidirectional Sanger Sequencing

Sample type: Peripheral blood in EDTA

Time to result: 3-4 weeks