What is Familial Mediterranean Fever?
Familial Mediterranean fever (FMF) is an inherited condition which causes episodic attacks of fever and painful inflammation of the abdomen, chest, and joints. FMF patiens may also develop a rash during these attacks. The episodes last for 1 to 3 days and can vary in severity. Between episodes the patient typically feels normal. These symptom-free periods can last for days or even years.
In 80-90% of people affected by FMF, the first episode occurs by the age of 20. Less commonly, symptoms begin later in life. Children who have FMF may experience periodic fever as their only symptom.
Some people with FMF develop a protein buildup in various parts of the body, notably the kidney. If left untreated, this can lead to life- threatening kidney failure. People who do not experience the characteristic features of FMF can still develop this particular form of kidney failure.
How is FMF diagnosed?
FMF is caused by mutations in MEFV gene. The condition has autosomal recessive inheritance.
More than 218 mutations have been described in MEFV gene. However no mutation can be detected in approximately 20-30% of FMf patients.
Genesis Genoma Lab offers two levels of analysis for Familial Mediterranean Fever: