Prenatal testing for fetal chromosomal abnormalities is now considered a necessary diagnostic test in obstetrics. Chorionic villi conventional karyotyping allows the detection of possible numerical and structural chromosomal abnormalities of the fetus. It is performed in the 1st trimester of pregnancy after chorionic villi sampling.
Indications for prenatal karyotyping are:
- Maternal age >35 years
- Abnormal biochemical or ultrasound findings
- Previous child with a chromosomal abnormality
- Parent carrier of a balanced chromosomal rearrangement
- Abnormal findings in non-invasive prenatal testing (NIPT)
Culture of chorionic villi cells and chromosome analysis using G-banding technique. Subsequent detailed microscopic analysis and chromosome pairing allows the detection of possible numerical and structural chromosomal abnormalities of sex and autosomal chromosomes.
Sample type: Chorionic villi sample in sterile tube containing transfer medium (provided by the laboratory)
Turnaround time: 3 weeks