Prenatal testing for fetal chromosomal abnormalities is now considered a necessary diagnostic test in obstetrics. Conventional karyotype of amniotic fluid cells allows the detection of possible numerical and structural chromosomal abnormalities of the fetus. It is performed in the 2nd trimester of pregnancy after amniocentesis.
Indications for prenatal karyotyping are:
- Maternal age >35 years
- Abnormal biochemical or ultrasound findings
- Previous child with a chromosomal abnormality
- Parent carrier of a balanced chromosomal rearrangement
- Abnormal findings in non-invasive prenatal testing (NIPT)
Culture of amniotic fluid cells and chromosome analysis using G-banding technique. Subsequent detailed microscopic analysis and chromosome pairing allows the detection of numerical and structural chromosomal abnormalities of sex and autosomal chromosomes.
Sample type: Amniotic fluid cells in sterile tube.
Turnaround time: 3 weeks